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作者前瞻性研究了格兰西酮、地塞米松对接受化疗和全身照射(TBI)预处理方案的骨髓移植(BMT)患者的止呕作用。26例中男11例,女15例,中位年龄40岁。BMT前预处理方案:全部患者接受环磷酰胺(CTX)60mg/kg,第1、2天,TBI 3Gy/d,共4天;14例第3天予噻替哌。5mg/kg,4例第3天接受足叶乙甙1500mg/M~2。格兰西酮1mgIVPB15分钟以上,随后地塞米松10mg IVPB,两种药物在第一次化/放疗前30分钟给予,1次/天,最后一次化/放疗后24h停药。呕吐未控制时加用格兰西酮Img IVPB,每24h一次作为急救,效果不佳或病情需要时加用甲
The authors prospectively studied the antiemetic effects of gersperidone and dexamethasone on bone marrow transplantation (BMT) patients receiving chemotherapy and total body irradiation (TBI) conditioning regimens. In 26 cases, there were 11 males and 15 females, with a median age of 40 years. Pre-BMT pretreatment protocol: All patients received cyclophosphamide (CTX) 60 mg/kg, on days 1 and 2, TBI 3 Gy/d for 4 days; 14 patients on day 3 received thiotepa. At the dose of 5 mg/kg, 4 patients received acetylephrine 1500 mg/M~2 on the third day. Glasgone 1 mg IVPB for more than 15 minutes, followed by dexamethasone 10 mg IVPB, both drugs were given 30 minutes before the first chemo/radiotherapy, 1 time/day, and 24 hours after the last chemo/radiotherapy. When vomiting is not controlled, add galsiridone Img IVPB, once every 24h as first aid, if the effect is poor or the condition is needed