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目的探讨2型糖尿病患者血清抵抗素与血脂及血糖相关性。方法 60例2型糖尿病患者(2dM组)和60例正常人(对照组)分别采取清晨空腹静脉血,应用酶联免疫吸附试验测定抵抗素,放射免疫分析法测定胰岛素,全自动生化分析仪检测血糖、血脂及肝功能指标。结果 2dM组的空腹血糖水平、空腹胰岛素、三酰甘油及抵抗素平均含量均显著高于对照组(P<0.05),而胆固醇、高密度脂蛋白、低密度脂蛋白在两组之间无明显差异(P>0.05)。结论糖尿病患者体内含有较高浓度的抵抗素,并存在血脂代谢异常和血糖水平的增高。
Objective To investigate the relationship between serum resistin and blood lipid and blood glucose in type 2 diabetic patients. Methods 60 fasting venous blood samples were collected from 60 patients with type 2 diabetes mellitus (2dM) and 60 normal persons (control group) respectively. Resistin was measured by enzyme linked immunosorbent assay (ELISA) and insulin by radioimmunoassay. Blood glucose, blood lipids and liver function indicators. Results The levels of fasting blood glucose, fasting insulin, triglyceride and resistin in 2dM group were significantly higher than those in control group (P <0.05), but cholesterol, high density lipoprotein and low density lipoprotein were not significantly different between the two groups Difference (P> 0.05). Conclusion Diabetic patients contain high concentrations of resistin, and there is abnormal lipid metabolism and blood glucose levels.