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目的:探讨半定量粪隐血试验最佳隐血阈值、能否区分不同的大肠出血性疾病以及对大肠癌筛检的作用。方法:连续截取100例门诊结肠镜检查患者,并于肠镜检查前收集两次新鲜粪便标本,同时进行半定量Baso Fecal OBⅡ(B试验)和Hemoccu lt(H试验)隐血检查。B试验的阳性结果按每克粪便血红蛋白含量记为(-)、(+)(50~200μg/g)、(2+)(200~2 000μg/g)、(3+)(2 000~4 000μg/g)及(4+)(>4 000μg/g)。H试验为定性试验,其结果记为(-)和(+)。P<0.05为具有统计学意义。结果:在B试验中,以≥(+)为大肠癌的阳性检出阈值,对大肠癌的检出敏感性和特异性均为90%,其检出敏感性高于H试验,是最佳敏感阈值。B试验结果显示,右半结肠癌出血量多于左半结肠癌(P<0.05)。结论:B试验有助于确定不同人群大肠癌的阳性检出阈值。如联合免疫化学隐血试验,将获得最佳的大肠癌检出效果。
Objective: To investigate the optimal occult blood threshold in semi-quantitative fecal occult blood test, whether it can distinguish different colorectal hemorrhagic diseases and the role of colorectal cancer screening. METHODS: One hundred patients with outpatient colonoscopy were consecutively harvested. Two fresh stool samples were collected before colonoscopy. Semiquantitative Baso Fecal OBII (B test) and Hemoccult (H test) occult blood tests were performed. The positive results of the B test were recorded as (-), (+) (50-200 μg/g), (2+) (200-2 000 μg/g), (3+) (2 000-4) of hemoglobin content per gram of stool. 000 μg/g) and (4+) (>4 000 μg/g). The H test was a qualitative test and the results were recorded as (-) and (+). P<0.05 was considered statistically significant. Results: In the B test, ≥(+) was the positive detection threshold of colorectal cancer. The detection sensitivity and specificity of colorectal cancer were 90%. The detection sensitivity was higher than that of the H test. Sensitive threshold. The results of the B test showed that the amount of bleeding in the right colon cancer was more than that in the left colon cancer (P < 0.05). Conclusion: The B test can help determine the positive detection threshold of colorectal cancer in different populations. Such as the combined immunochemistry occult blood test, will get the best detection of colorectal cancer.