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目的 :探讨 E-CD与胃癌临床病理的关系。方法 :应用免疫组织化学方法( Ls AB法 )检测胃癌及胃炎病变中 E-CD的表达。结果 :胃癌中 E-CD表达明显减弱 ( 3 2 / 44 ,P<0 .0 1 )。 E-CD的表达在胃癌的大体类型间呈显著性差异 ( P<0 .0 5) ,与浸润程度及淋巴结转移与否呈极显著性差异 ( P<0 .0 1 ) ,而与分化程度无关 ( P>0 .0 5)。结论 :E-CD与胃癌的生长方式、浸润程度、淋巴结转移有相关性
Objective: To investigate the relationship between E-CD and clinicopathological features of gastric cancer. Methods: The expression of E-CD in gastric cancer and gastritis was detected by immunohistochemistry (LS AB). Results: E-CD expression was significantly decreased in gastric cancer (32/44, P <0.01). The expression of E-CD was significantly different between the general types of gastric cancer (P <0.05) and the degree of infiltration and lymph node metastasis (P <0.01), but not with the degree of differentiation Not related (P> 0.05). Conclusion: There is a correlation between E-CD and gastric cancer growth pattern, infiltration degree and lymph node metastasis