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目的:探讨血浆降钙素基因相关肽(CGRP)和内皮素(ET)水平变化与高原地区子前期患者发病的关系。方法:采用放射免疫法对高原地区重度子前期患者31例和正常晚孕妇女30例,分别于产前及产后1周进行血浆CGRP和ET水平测定。结果:产前重度子前期患者血浆CGRP含量(71.71±3.75 ng/L)明显低于正常晚孕妇女(110.51±7.55 ng/L)(P<0.01),而血浆ET含量(68.96±11.27 ng/L)明显高于正常晚孕妇女(44.70±4.46 ng/L)(P<0.01)。与正常产妇比较,产后1周时子前期患者病情明显缓解,其血浆CGRP(101.21±7.46 ng/L)上升(P<0.01),血浆ET(51.89±7.87 ng/L)下降,接近正常产后水平(P>0.05)。结论:血浆CGRP和ET水平变化是反映高原地区重度子前期患者发病及衡量病情的重要因素。
Objective: To investigate the relationship between plasma levels of calcitonin gene-related peptide (CGRP) and endothelin (ET) and the incidence of pre-clinical stage patients in the plateau region. Methods: Thirty-one patients with severe preeclampsia and 30 normal pregnant women in the plateau were measured by radioimmunoassay. Plasma CGRP and ET levels were measured at prenatal and postnatal week respectively. Results: The plasma levels of CGRP (71.71 ± 3.75 ng / L) were significantly lower in prenatal severe preeclampsia than those in normal pregnant women (110.51 ± 7.55 ng / L) (P <0.01), while the plasma levels of ET (68.96 ± 11.27 ng / L) was significantly higher than that of normal pregnant women (44.70 ± 4.46 ng / L) (P <0.01). Compared with normal maternal, preeclampsia patients’ condition was relieved significantly at 1 week postpartum. Plasma CGRP (101.21 ± 7.46 ng / L) increased (P <0.01) and plasma ET (51.89 ± 7.87 ng / L) > 0.05). Conclusion: The changes of plasma CGRP and ET levels are important factors that reflect the onset of severe pre-eclampsia and the severity of disease in the plateau.