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现在市售的降压药其临床试验都不是以妊娠高血压患者为对象应用对照药加以实施的。根据临床试验,应用较广的降压药是α-甲基多巴和肼苯哒嗪。α-甲基多巴可通过胎盘进入胎儿体内,但迄今尚无对胎儿产生副作用及障碍发生的报告。该药每日用量250～1500mg,可引起母体口渴、嗜睡、直立性低血压等副作用。肼苯哒嗪亦可通过胎盘进入胎体,并可使家兔、小鼠致畸。有人报告,孕妇服用本品后可使新生儿血小板和白细胞减少、皮下出血、血肿等。这些副作用在出生后1～3周消失。肼苯哒嗪每日用量为30～
Now the clinical trials of antihypertensive drugs are not on the basis of pregnancy-induced hypertension in patients with control drugs to be implemented. According to clinical trials, widely used antihypertensive drugs are α-methyl-dopa and hydralazine. α-Methyl Dopa can enter the fetus through the placenta, but so far there are no reports of side effects and obstacles to the fetus. The daily dose of 250 ~ 1500mg, can cause maternal thirst, lethargy, orthostatic hypotension and other side effects. Hydralazine can also enter the carcass through the placenta, and can make rabbits, mice teratogenic. It was reported that pregnant women taking this product can make neonatal platelets and leukopenia, subcutaneous hemorrhage, hematoma and so on. These side effects disappear 1 to 3 weeks after birth. Hydralazine daily dosage of 30 ~