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目的:探究屈螺酮炔雌醇片治疗对药物流产后宫内组织物残留率的影响。方法:选取广州市妇女儿童医疗中心2015年1月至2016年12月妇产科收治孕9~13周且需药物流产孕妇200例,随机均分为研究组及对照组,每组各100例。两组孕妇均给予米非司酮配伍米索前列醇进行药物流产,待药物流产成功后,对照组孕妇给予益母草胶囊进行治疗,在此基础上研究组孕妇给予屈螺酮炔雌醇片治疗。经治疗后,观察两组孕妇阴道流血及宫内组织物残留情况。结果:经治疗后,研究组孕妇阴道流血持续时间为(5.12±1.36)d明显短于对照组孕妇(9.02±2.11)d,差异具有统计学意义(P<0.05);研究组孕妇阴道流血止血率(95%)明显高于对照组(85%),差异具有统计学意义(P<0.05);药物流产2周后,两组孕妇宫内组织物残留率相比,差异无统计学意义(P>0.05),第1次月经后、第2次月经后B超检查,观察组孕妇宫内组织物残留率均明显低于对照组,差异具有统计学意义(P<0.05)。结论:对药物流产后孕妇采用屈螺酮炔雌醇片治疗可明显改善宫内组织物残留情况,保护子宫内膜。
Objective: To investigate the effect of drospirenone ethinyl estradiol tablets on the residual rate of intrauterine tissue after medical abortion. Methods: Guangzhou Women and Children Medical Center from January 2015 to December 2016 Obstetrics and Gynecology admitted to 9 to 13 weeks of pregnancy and required medical abortion pregnant women 200 cases were randomly divided into study group and control group, 100 cases in each group . Both groups of pregnant women were given mifepristone with misoprostol for medical abortion. After the medical abortion was successful, pregnant women in the control group were treated with Motherwort Capsules. On the basis of this study, pregnant women in the study group were given drospirenone ethinyl estradiol tablets. After treatment, two groups of pregnant women were observed vaginal bleeding and intrauterine tissue residue. Results: After treatment, the duration of vaginal bleeding in the study group was significantly shorter (5.12 ± 1.36) d than that in the control group (9.02 ± 2.11) d, the difference was statistically significant (P <0.05) (95%) was significantly higher than that of the control group (85%), the difference was statistically significant (P <0.05). After two weeks of medical abortion, there was no significant difference in the intrauterine tissue residual rate between the two groups P> 0.05). After the first menstruation, the second postmenopausal B-ultrasound examination, the intrauterine tissue residual rate in the observation group were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Treatment of abortion with drospirenone ethinyl estradiol can significantly improve the intrauterine tissue residue and protect the endometrium.