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用小鼠 S_(180)肿瘤细胞作为靶细胞,以~3H-TdR 的掺入抑制百分率作为抗肿瘤活性的指标,在体外培养条件下,S-O_2-1 菌苗能刺激正常小鼠及带瘤小鼠的免疫活性细胞,释放对 S_(180)肿瘤细胞 DNA 合成有明显抑制作用的可溶性物质。实验提示,该类免疫因子的产生能增强免疫细胞对肿瘤细胞的细胞毒效应。同时发现 S-O_2-1菌苗本身对 S_(180)肿瘤细胞还具有直接杀伤作用。
Using S_ (180) tumor cells of mice as target cells, the inhibitory percentage of incorporation of ~ 3H-TdR was taken as an indicator of antitumor activity. Under in vitro culture conditions, S-O_2-1 vaccine could stimulate normal mice and belts The immunocompetent cells in tumor-bearing mice release soluble substances that significantly inhibit the DNA synthesis of S 180 tumor cells. Experiments show that the production of such immune factors can enhance the cytotoxic effect of immune cells on tumor cells. At the same time, it was found that the S-O_2-1 vaccine itself has a direct killing effect on S 180 tumor cells.