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家兔尾核薄片(0.35mm)于37℃与[~3H]DA孵育30min后,放入灌流装置中持续灌流。施予两次电场刺激诱发两个[~3H]DA释放峰S_1和S_2。药物在第一次电刺激后引入灌流液中,以S_2/S_1比值代表药物效应。实验结果表明,对照组脑片S_2/S_1为0.79±0.06,新型DA受体阻滞剂1-SPD 10~(-5)-10~(-12)M,使S_2/S_1分别增为2.60±
Rabbit caudate nucleus (0.35 mm) was incubated with [~ 3H] DA for 30 min at 37 ° C and then placed in a perfusion device for continuous perfusion. Two [~ 3H] DA release peaks, S_1 and S_2, were induced by two electric field stimuli. The drug was introduced into the perfusate after the first electrical stimulation and the drug effect was represented by the S 2 / S 1 ratio. The experimental results showed that S_2 / S_1 in the control group was 0.79 ± 0.06 and that of the new DA receptor antagonist 1-SPD 10 ~ (-5) -10 ~ (-12) M increased S 2 / S 1 to 2.60 ±