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目的观察多巴胺联合纳洛酮治疗中、重度新生儿缺氧缺血性脑病的疗效。方法对84例新生儿缺氧缺血性脑病患儿随机分为两组:对照组给予对症及支持等常规综合治疗。治疗组在对照组治疗基础上,加用小剂量多巴胺2μg/(kg·min),输液泵维持24 h静脉输注,连用2～5 d,同时加用纳洛酮0.1 mg/(kg·d)加入10%葡萄糖液40 ml持续静脉点滴,维持4～6 h,连用3～7 d。观察两组患儿意识恢复时间、肌张力恢复时间、反射恢复时间和不良反应。结果治疗组意识恢复时间、肌张力恢复时间、反射恢复时间与对照组比较有显著差异(P<0.05)。结论多巴胺联合纳洛酮治疗中、重度新生儿缺氧缺血性脑病疗效显著。
Objective To observe the efficacy of dopamine combined with naloxone in the treatment of moderate and severe hypoxic-ischemic encephalopathy. Methods Eighty-four neonates with hypoxic-ischemic encephalopathy were randomly divided into two groups: the control group was given symptomatic and supportive conventional comprehensive treatment. The treatment group was treated with low dose of dopamine 2μg / (kg · min) on the basis of the control group. The infusion pump was maintained for 24 hours by intravenous infusion for 2 ~ 5 days. Naloxone 0.1 mg / (kg · d) ) Add 10% glucose solution 40 ml continuous intravenous drip, maintain 4 ~ 6 h, once every 3 ~ 7 d. The recovery time, muscle tone recovery time, reflex recovery time and adverse reactions in both groups were observed. Results The recovery time, muscle tone recovery time and reflex recovery time in the treatment group were significantly different from those in the control group (P <0.05). Conclusion Dopamine combined with naloxone in the treatment of moderate and severe hypoxic-ischemic encephalopathy has a significant effect.