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由秋水仙硷处理培养的淋巴细胞所制备的染色体,在正常情况下产生分散良好的中期分裂相。发生着丝粒分裂(cleft)的染色体与特定环境和典型的细胞学特征有关。在多数病例,着丝粒分裂的机理不完全清楚。作者认为所有这样现象通称为“早熟着丝粒分裂综合征”是不能反映其分离的本质。C-后期与秋水仙硷抗性突变培养的淋巴细胞制备染色体需二个主要步骤:植物血凝素刺激和秋水仙硷阻断,分别导致分裂球丝转化和有丝分裂中期延长。根据不同个体对这两种药物的不同反应,可
Chromosomes prepared from colchicine-treated lymphocytes, under normal conditions, produce a well-dispersed metaphase. Chromosomes that undergo centromere cleft are associated with a particular environment and with typical cytological features. In most cases, the mechanism of centromere division is not completely understood. The author believes that all such phenomena commonly known as “premature centromere syndrome” can not reflect the essence of its separation. C-Late and Colchicine-Resistant Mutations Cultured lymphocytes require two major steps: phytohemagglutinin stimulation and colchicine blockade, leading to mitotic filament conversion and metaphase elongation, respectively. Depending on the different reactions of these two drugs to different individuals,