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研究醛糖还原酶抑制剂防治糖尿病肾脏病变的意义。利用糖尿病ＳＤ大鼠动物模型观察了醛糖还原酶抑制剂ｓｏｒｂｉｎｉｌ对大鼠尿蛋白和肾脏超微结构的影响。结果：糖尿病鼠用ｓｏｒｂｉｎｉｌ治疗后尿蛋白呈下降趋势，肾小球基底膜厚度及系膜基质堆积明显减少。结论： ｓｏｒｂｉｎｉｌ对肾脏病变有明显疗效，使用醛糖还原酶抑制剂防治糖尿病肾病将是一条有希望的新路。
To study the significance of aldose reductase inhibitors in prevention and treatment of diabetic nephropathy. The effects of aldose reductase inhibitor sorbinil on urinary protein and renal ultrastructure in diabetic SD rats were observed. Results: After diabetic rats treated with sorbinil urine protein decreased, the glomerular basement membrane thickness and mesangial matrix accumulation was significantly reduced. Conclusion: sorbinil has obvious curative effect on nephropathy. Using aldose reductase inhibitor to prevent and treat diabetic nephropathy will be a promising new way.