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目的:回顾性分析贵州省黔西南州人民医院新生儿多重耐药菌(MDRO)感染性肺炎的病原菌分布及耐药情况,为合理用药提供依据。方法:选取2011年3月至2012年2月该院新生儿病房确诊的MDRO感染性肺炎62例为研究对象,分析病原菌种类及其药敏试验结果。结果:62例MDRO中革兰阴性菌51例,占82.3%,革兰阳性菌11例,占17.7%。革兰阴性菌主要为大肠埃希菌、肺炎克雷伯菌,其对亚胺培南、美罗培南敏感率为100%,对哌拉西林/他唑巴坦敏感率为94.1%。革兰阳性菌均为葡萄球菌,对万古霉素敏感率为100%。结论:该院新生儿MDRO感染性肺炎的主要病原菌为革兰阴性菌中的大肠埃希菌、肺炎克雷伯菌,治疗首选亚胺培南、美罗培南,因其对哌拉西林/他唑巴坦敏感率也高,且哌拉西林/他唑巴坦价格低廉,故哌拉西林/他唑巴坦可作为优选药。
OBJECTIVE: To retrospectively analyze the distribution and drug resistance of pathogenic bacteria in neonatal multi-drug resistant pneumonia (MDRO) in Guizhou Qianxinan People’s Hospital, so as to provide basis for rational drug use. Methods: From March 2011 to February 2012, 62 cases of MDRO pneumonia confirmed in newborn ward of the hospital were selected as research objects, and the types of pathogenic bacteria and their drug susceptibility test results were analyzed. Results: Of the 62 patients with MDRO, 51 were Gram-negative bacteria, accounting for 82.3%, while 11 were Gram-positive bacteria, accounting for 17.7%. Gram-negative bacteria mainly Escherichia coli, Klebsiella pneumoniae, its imipenem, meropenem sensitivity was 100%, the sensitivity rate to piperacillin / tazobactam was 94.1%. Gram-positive bacteria are staphylococci, the sensitivity of vancomycin is 100%. Conclusion: The main pathogens of neonatal MDRO pneumonia in this hospital are Escherichia coli and Klebsiella pneumoniae in Gram-negative bacteria, the preferred treatment imipenem and Meropenem, Badan sensitivity is also high, and piperacillin / tazobactam low prices, so piperacillin / tazobactam can be used as a preferred drug.