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目的 :研究右心室流出道的电生理特性 ,并探讨其与心室流出道心律失常的关系。方法 :利用细胞内微电极记录技术 ,观察豚鼠右心室流出道组织的电活动特性。结果 :在 2 3例豚鼠右室流出道组织标本中 4例 ( 17.39% )可记录到自律性电活动。在紧靠瓣膜下及流出道光滑部的局部区域可记录到非自律性慢反应电位 (MDP :6 2 .2 8± 8.14mv ,APA :6 5 .2 2± 15 .18mV ,Vmax :2 2 .2 7± 8.13v/s,APD90 :176 .2 4± 10 .13ms ,APD5 0 :12 3.4 7± 12 .36ms)及形态不典型的自律性慢反应电位 ,其 0相去极化速度、幅度及动作电位时程变异较大。大部分区域为非自律快反应动作电位 (MDP :71.2 3± 6 .6 2mv ,APA :79.33± 5 .4 8mV ,Vmax :10 3.13± 9.0 3v/s,APD90 :16 6 .2 3± 2 0 .33ms ,APD5 0 :12 6 .33± 16 .2 6ms) ,其特征与普通心室肌细胞动作电位相似。结论 :右心室流出道组织的电生理特性与普通心室肌不同 ,其自律性和电生理异质性可能是某些流出道心律失常的电生理学基础。
Objective: To study the electrophysiological characteristics of right ventricular outflow tract and to explore its relationship with ventricular outflow tract arrhythmia. Methods: The intracellular microelectrode recording technique was used to observe the electrical activity of right ventricular outflow tract in guinea pigs. RESULTS: Four cases (17.39%) of right ventricular outflow tract specimens from 23 guinea pigs could record self-regulated electrical activity. Non-voluntary slow response potentials (MDP: 62.28 ± 8.14 mv, APA: 6.52.2 ± 15.18 mV, Vmax: 2 2 were recorded in the subregion and in the subregion of the smooth portion of the outflow tract .2 7 ± 8.13v / s, APD90: 176.24 ± 10.13ms, APD5 0: 12 3.4 7 ± 12.36ms), and atypical autonomic slow response potentials with 0-phase depolarization velocity and amplitude And the action potential variation in time course. Most of the regions were non-autonomic fast response action potentials (MDP: 71.2 3 ± 6. 62mv, APA: 79.33 ± 5.58mV, Vmax: 10 3.13 ± 9.0 3v / s, APD90: 16 6 .23 ± 20 .33 ms, APD5 0: 12 6 .33 ± 16 .2 6 ms), which is characteristic of the action potential of common ventricular myocytes. CONCLUSION: The electrophysiological characteristics of right ventricular outflow tract are different from those of common ventricular muscle. Their autonomic and electrophysiological heterogeneity may be the electrophysiological basis of some outflow tract arrhythmias.