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目的探讨紫杉醇和奈达铂化疗联合放疗对中晚期宫颈癌患者的临床疗效。方法随机选取2011年8月至2015年8月收治的70例中晚期宫颈癌患者作为临床研究对象,按随机数字表法分为观察组和对照组,每组35例。对照组采用常规放疗,观察组在对照组的基础上联合紫杉醇和奈达铂化疗,比较两组患者临床疗效、复发转移率,观察患者不良反应发生情况。结果观察组治疗有效率为88.57%,显著高于对照组(65.71%),差异有统计学意义(P<0.05);在近期疗效、复发转移率方面,观察组治疗效果均优于对照组,差异有统计学意义(P<0.05)。结论对中晚期宫颈癌患者的治疗,采用紫杉醇、奈达铂化疗联合放疗疗效更显著,值得临床推广和应用。
Objective To investigate the clinical effect of paclitaxel and nedaplatin combined with radiotherapy on patients with advanced cervical cancer. Methods Seventy patients with advanced cervical cancer who were admitted to our hospital from August 2011 to August 2015 were randomly divided into observation group and control group according to random number table method, with 35 cases in each group. The control group received conventional radiotherapy. The observation group was treated with paclitaxel and nedaplatin on the basis of the control group. The clinical efficacy, recurrence and metastasis rate were compared between the two groups, and the incidence of adverse reactions was observed. Results The effective rate of observation group was 88.57%, which was significantly higher than that of control group (65.71%), the difference was statistically significant (P <0.05). The curative effect and recurrence and metastasis rate of observation group were better than that of control group, The difference was statistically significant (P <0.05). Conclusion The treatment of patients with advanced cervical cancer, the use of paclitaxel, nedaplatin chemotherapy combined with radiotherapy more significant effect, worthy of clinical promotion and application.