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静脉畸形(VMs)由扩张的静脉及不连续的平滑肌细胞构成,内皮细胞酪氨酸激酶受体TIE2基因激活是常见原因。VMs常常引起畸形、疼痛和局部血管内凝血,随时间延长,症状逐渐加重。目前,尚无法使用靶向药物治疗。该文介绍一种通过将表达突变体TIE2-L914F的HUVECs注射入免疫缺陷鼠体
Venous malformations (VMs) consist of dilated veins and discontinuous smooth muscle cells, and activation of the endothelial cell tyrosine kinase receptor TIE2 gene is a common cause. VMs often cause deformity, pain and local vascular coagulation, with the passage of time, the symptoms gradually aggravated. At present, there is no way to use targeted drug therapy. This article describes a method by injecting HUVECs expressing mutant TIE2-L914F into immunodeficient mice