论文部分内容阅读
目的:观察经痛宁方对气滞血瘀型原发性痛经对患者血清前列腺素2α(PGF2α)、一氧化氮(NO)、催产素(OT)的影响。方法:将80例患者随机分为2组各40例,治疗组采用经痛宁方治疗,对照组采用元胡止痛片治疗,观察2组患者临床疗效及治疗前后血清PGF2α、OT、NO的变化。结果:总有效率治疗组为90.0%,对照组为67.5%,2组比较,差异有显著性意义(P<0.05)。治疗后2组患者血清PGF2α、OT水平均较治疗前均明显降低(P<0.01),NO水平均较治疗前明显升高(P<0.01);且治疗组以上各项指标改善较对照组更为显著,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:经痛宁方治疗气滞血瘀型原发性痛经发挥疗效的作用机制可能与降低患者血清PGF2α、OT水平,升高NO水平有关。
Objective: To observe the effect of Jingtongningfang on the serum levels of prostaglandin 2α (PGF2α), nitric oxide (NO) and oxytocin (OT) in patients with qi stagnation and blood stasis type dysmenorrhea. Methods: Eighty patients were randomly divided into two groups of 40 cases. The treatment group was treated with Jintongningfang and the control group with Yuanhu Zhitong Tablet. The clinical curative effect and the changes of serum PGF2α, OT, NO before and after treatment were observed. Results: The total effective rate was 90.0% in the treatment group and 67.5% in the control group. There was significant difference between the two groups (P <0.05). After treatment, serum PGF2α and OT levels in both groups were significantly lower than those before treatment (P <0.01), and NO levels were significantly higher than those before treatment (P <0.01); and the above indexes in the treatment group improved more than those in the control group As significant, the difference was significant or very significant (P <0.05, P <0.01). Conclusion: The mechanism of JTTF on treating primary dysmenorrhea with qi stagnation and blood stasis type may be related to decreasing serum PGF2α and OT levels and increasing NO levels.