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目的 观察卡维地洛对原发性高血压 (EH)患者心率变异性的影响。方法 4 2例高血压患者每日服卡维地洛 2 0mg,观察 8周。记录用药前后血压、心率及 2 4小时动态心电图 ,分析心率变异 (HRV)时域和频域指标 ,并与 4 2例健康对照组比较。结果 与对照组相比 ,EH患者相邻正常R R间期标准差(SDNN)、正常相邻R R间期差值的方差 (RMSSD)及高频功率 (HF)均明显下降 ,低频功率 /高频功率值 (LF/HF)增加。用卡维地洛后血压从 (15 5 .5± 17.1) / (10 0 .9± 5 .6 )mmHg下降至 (14 7.8± 14 .4 ) / (88.7± 3.6 )mmHg (P <0 .0 1) ,心率从 (79.5± 10 .1)次 /min下降至 (6 6 .1± 7.5 )次 /min(P <0 .0 1) ,同时SDNN、RMSSD、HF增加 ,LF/HF值降低。结论 卡维地洛可提高原发性高血压患者的心率变异性 ,改善自主神经功能。
Objective To observe the effect of carvedilol on heart rate variability in patients with essential hypertension (EH). Methods Forty-two hypertensive patients received carvedilol 20 mg daily for 8 weeks. The blood pressure, heart rate and 24 hours ambulatory ECG were recorded before and after treatment. HRV time-domain and frequency-domain indexes were analyzed and compared with 42 healthy controls. Results Compared with the control group, the standard deviation (SDNN) of adjacent normal RRH, RMSSD and HF of normal adjacent RR interval decreased significantly, while low frequency power / high frequency The power value (LF / HF) increases. Blood pressure decreased from (15.5 ± 17.1) / (10.9 ± 5.6) mmHg to (14.88 ± 14.4) / (88.7 ± 3.6) mmHg after carvedilol treatment (P <0. Heart rate decreased from (79.5 ± 10.1) times / min to (6.6 ± 7.5) times / min (P <0.01), meanwhile SDNN, RMSSD, HF increased and LF / HF value increased reduce. Conclusion Carvedilol can improve heart rate variability and improve autonomic nervous function in patients with essential hypertension.