【摘 要】
：
作为传统抗生素有力的候选者,抗菌肽是先天免疫体系中的重要组成成分.抗菌肽从起初的接触至随后稳定地吸附到细菌CC的质膜之上,是抗菌肽发挥其抗菌功能的关键初始事件.为揭示
【基金项目】
：
广东省工业攻关项目;国家自然科学基金
论文部分内容阅读
作为传统抗生素有力的候选者,抗菌肽是先天免疫体系中的重要组成成分.抗菌肽从起初的接触至随后稳定地吸附到细菌CC的质膜之上,是抗菌肽发挥其抗菌功能的关键初始事件.为揭示这一尚未明了的过程,文中使用分子动力学模拟方法,通过构建抗菌肽HP(2-20)与POPE脂双层的体系,模拟了HP(2-20)与POPE脂膜间的非特异相互作用.结果表明:抗菌肽的N端最先与脂膜接触,随后抗菌肽将维持一种倾斜的姿态,经历一个旋动插入脂膜的过程；同时,抗菌肽将束缚膜上与其邻近的磷脂分子的运动,导致膜的不均匀性,增强脂膜磷脂分子的无序波动,为其它自由的抗菌肽分子更深的插入提供了机会.
其他文献
The effect of NdCl_3 on the rooting and nitrogen metabolism of loquat in vitro was studied when NdCl_3 was added to the rooted medium. The results show that 0.4
The enantioselective esterification of racemic 1-trimethylsilylethanol with acids catalyzed by lipase in organic solvent was successfully performed.The influenc
The erosion resistance tests were used to research the erosion wear behavior of CaO-Al2O3-SiO2 system glass-ceramic. With the orthogonal test method, the factor
Although humans have spent exactly 100 years combating Alzheimer's disease (AD), the molecular mechanisms of AD remain unclear. Owing to the rapid growth of the
A theoretical model of relationship between subsurface damage and surface roughness was established to realize rapid and non-destructive measurement of subsurfa
人群仿真目前在工业、建筑、交通等多种领域中应用广泛。实现复杂场景中的人群运动实时仿真,效率是亟待解决的关键性问题,而提高仿真效率所必须面临的挑战主要有人群的渲染、位置及状态的实时更新和碰撞检测。提出一种基于场的方法来实现人群运动的实时仿真,通过构建导航场和密度场引导人群运动。导航场能够引导人群按最优可行路径到达其目标位置;而密度场通过对人群运动速度的影响,再与基于GPU的碰撞检测方法结合,有效地避
Phytolacca is the biggest and most original genus in Phytolaccaceae and an important genus in plant systematic studies. Light microscopy results show that the P
The origin of angiosperms has been a focus of intensive research for a long time. The so-called preCretaceous angiosperms, including Schmeissneria, are usually
针对深圳某220 kV同杆双回线路改造为4回线路后出现严重不平衡电流的特殊问题,利用电磁暂态程序EMTDC建立同杆多回线分相参数模型,研究了相序排列、线路潮流和环网运行对同杆