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[目的]探讨MMP9-1562位点基因多态性在老年冠心病患者和正常人群中的分布与冠心病的相关性。[方法]采用聚合酶链反应-限制性片断长度多态性技术对96例老年冠心病中患者及78例正常人MMP9-1562位点基因多态性进行研究,同时检测血清MMP9水平。[结果]冠心病患者血清MMP9水平显著高于对照组(P﹤0.01),其1562位点基因多态性在冠心病患者与健康对照组间分布差异有统计学意义(P﹤0.01),其中携带T等位基因个体患冠心病的风险是C等位基因的1.658倍。[结论]MMP9-1562位点基因多态性可能与冠心病的发病相关,血清MMP9水平受其基因多态性的影响。
[Objective] To investigate the relationship between the distribution of MMP9-1562 gene polymorphism and coronary heart disease in elderly patients with coronary heart disease and normal subjects. [Method] Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the gene polymorphism of MMP9-1562 in 96 elderly patients with coronary heart disease and 78 normal subjects. The level of serum MMP9 was also measured. [Results] The serum level of MMP9 in patients with coronary heart disease was significantly higher than that in the control group (P <0.01). The gene polymorphism at the 1562 locus in patients with coronary heart disease was significantly different from that in healthy controls (P <0.01) The risk of coronary heart disease in individuals carrying the T allele is 1.658 times that of the C allele. [Conclusion] The gene polymorphism of MMP9-1562 may be related to the pathogenesis of coronary heart disease. The level of serum MMP9 is influenced by its gene polymorphism.