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新型隐球菌是一种酵母样霉菌,通过呼吸道感染,通常对人并不造成危害,但有一些人容易受到感染而成为严重的隐球菌病,特别是患恶性肿瘤、类肉瘤病、胶原性疾病、糖尿病以及应用类固醇和免疫抑制剂的患者。它侵犯中枢神经系统、肺、骨骼、皮肤、淋巴结和内脏。明显的CNS感染如果不予治疗,可导致死亡。其临床表现为慢性脑膜炎、脑炎、颅内占位性病变征和痴呆。对肺、骨或皮肤孤立的隐球菌病灶进行外科手术切除可以收效。但有促致播散的危险性,所以某些作者主张并用化疗,在60年代末,是应用二性霉素B。
Cryptococcus neoformans is a yeast-like mold that normally does not cause harm to humans through the respiratory tract, but some are susceptible to severe cryptococcosis, particularly with malignant tumors, sarcoidosis, and collagen disorders , Diabetes, and patients on steroids and immunosuppressants. It affects the central nervous system, lungs, bones, skin, lymph nodes and internal organs. Significant CNS infections can result in death if left untreated. The clinical manifestations of chronic meningitis, encephalitis, intracranial space-occupying lesions and dementia. Surgical resection of cryptococcal lesions isolated from the lung, bone or skin can be effective. But there is the danger of causing dissemination, so some authors advocate and use chemotherapy, in the late 1960s, is the application of amphotericin B.