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子宫是松弛素的一个靶器官,松弛素能特异性地抑制子宫收缩并使妊娠得以维持.足月子宫的蜕膜组织提取物中含有大量松弛素.但是,早年的实验提示,粗蜕膜组织制备对子宫活动的影响变化很大,甚至可能观察到异相的刺激作用.而且,只有用经柱层析纯化的样品,才能完全表现出松弛素对子宫的作用.实验证明,蜕膜能分泌催乳素,而经柱层析可将松弛素与催乳素分开.作者发现在不纯的蜕膜样品中含有催乳素.为了阐明松弛索对子宫的作用是否受到粗提物中混有的催乳素的掩盖或拮抗作用,作者用离体的大鼠子宫研究了纯的人催乳素和高催乳素的血清对子宫活动的影响,以及与猪的松弛素合用时的影响.
The uterus is a target organ for relaxin that specifically inhibits uterine contractions and allows pregnancy to be maintained.Conclusion: There are a large number of relaxin in the decidua extract of the full-term uterus, but early experiments suggested that crude decidual tissue The effect of preparation on uterine activity varies widely, and even heterophase stimulation may be observed, and the effect of relaxin on the uterus can only be fully demonstrated by samples purified by column chromatography. Experiments have shown that deciduals can secrete Prolactin, and column chromatography can be separated from prolactin and relaxin.I found in impure decidua samples contain prolactin.In order to elucidate the role of the relaxation of the uterus by crude extract mixed with prolactin The authors used an isolated rat uterus to study the effect of pure human prolactin and high-prolactin serum on uterine activity and their effect on porcine relaxin.