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TT病毒(TTV)是一种新发现的输血相关DNA病毒,它可引起输血后肝炎。在日本供血者中,检出率为12％。本研究是为了调查在骨髓移植(BMT)受者中TTV的流行率和临床影响。25例BMT受者在移植后6～12周时采集血样,用半巢式PCR法检测TTV-DNA。移植后,25例受者中有15例(60％)TTV-DNA为阳性。而20例供者中只有2例(10％)为阳性。移植前TTV-DNA为阳性的受者在移植后的骨髓抑制期间其TTV-DNA数量下降到检测水平以下。作者使用核酸序列分析发现了一个新的TTV亚型,G3。在TTV阳性和阴性的受者中,其
The TT virus (TTV) is a newly discovered transfusion-associated DNA virus that causes post-transfusion hepatitis. In Japanese blood donors, the detection rate was 12%. This study was conducted to investigate the prevalence and clinical impact of TTV in bone marrow transplant recipients. Twenty-five BMT recipients collected blood samples 6 to 12 weeks after transplantation and detected the TTV-DNA by semi-nested PCR. TTV-DNA was positive in 15 (60%) of the 25 recipients after transplantation. While only 2 out of 20 donors (10%) were positive. TTV-DNA-positive recipients prior to transplantation have their TTV-DNA number decreased below detection level during post-transplant myelosuppression. The authors used nucleic acid sequence analysis to discover a new TTV subtype, G3. Among TTV-positive and -negative recipients, it is