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Objective To improve the prognosis and therapeutic efficacy of Waldeyer’s ring non Hodgkin lymphoma (NHL WR), combined radio chemotherapy was used to treat the patients with NHL WR and prognostic factors were analyzed Methods Ninety patients with stage Ⅰ～Ⅳ NHL WR were treated with combined radio chemotherapy 4000?cGy to 6000?cGy were given to Waldeyer’s ring structure and involved cervical nodes Uninvolved low cervical nodes received 3000?cGy to 4000?cGy The combination chemotherapy consisted of COPP (cyclophosphamide [CTX], vincristine [VCR], procarbazine [PCZ], prednisone [PDN]) or CHOP (CTX, ADM, VCR and PDN) Univariate analysis was performed to determine the prognostic unfavorable factors Results Five year overall survival rate was 69 7% for the whole group, and 83 2% for patients with stage Ⅰ, Ⅱ In univariate analyses, over survival (OS) rates of the patients with low and intermediate grade (76 1%), with stage Ⅰ, Ⅱ (83 2%), without fever (75 2%) and with performance status (PS) 0, 1 (85 7%) were significantly better than those of the patients with high grade (53 0%), with stage Ⅲ, Ⅳ (24 7%) with fever (38 5%), with PS2 (41 7%), PS 3, 4 (0 0%), respectively ( P <0 05) Conclusions Combined radio chemotherapy can improve the 5 year survival rate for the patients with NHL WR, especially for stage Ⅰ, Ⅱ patients PS2, stage Ⅲ, Ⅳ, fever and high grade histology were associated with unfavorable prognosis
Objective To improve the prognosis and therapeutic efficacy of Waldeyer’s ring non Hodgkin lymphoma (NHL WR), combined radio chemotherapy was used to treat the patients with NHL WR and prognostic factors were analyzed method Ninety patients with stage I-IV NHL WR were treated with combined combined Radio chemotherapy 4000?cGy to 6000?cGy were given to Waldeyer’s ring structure and involved cervical nodes Uninvolved low cervical nodes received 3000?cGy to 4000?cGy The combination scheme include of COPP (cyclophosphamide [CTX], vincristine [VCR], procarbazine [ PCZ], prednisone [PDN]) or CHOP (CTX, ADM, VCR and PDN) Univariate analysis was performed to determine the prognostic unfavorable factors Results Five year overall survival rate was 69 7% for the whole group, and 83 2% for patients With stage I, II In univariate analyses, over survival (OS) rates of the patients with low and intermediate grade (76 1%), with stage I, II (83 2%), withou t fever (75 2%) and with performance status (PS) 0, 1 (85 7%) were significantly better than those of the patients with high grade (53 0%), with stage III, IV (24 7%) with Fever (38 5%), with PS2 (41 7%), PS 3, 4 (0 0%), respectively ( P <0 05) Conclusions Combined radio chemotherapy can improve the 5 year survival rate for the patients with NHL WR, Especially for stage I, II patients PS2, stage III, IV, fever and high grade histology were associated with unfavorable prognosis