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目的探讨血清水通道蛋白4抗体(AQP4-Ab)在中枢神经系统脱髓鞘疾病中的诊断价值。方法选取玉林市第一人民医院2013年8月—2016年11月收治的中枢神经系统脱髓鞘疾病患者98例,测定血清AQP4-Ab的生理活性物质。结果本研究中,横贯性脊髓炎(TM)患者的AQP4-Ab阳性检出率为27.78%(5/18);视神经炎(ON)患者的AQP4-Ab阳性检出率为13.33%(2/15);视神经脊髓炎(NMO)患者的AQP4-Ab阳性检出率为43.48%(10/23);多发性硬化(MS)患者的AQP4-Ab阳性检出率为10.00%(2/20);非长节段横贯性脊髓炎(n LETM)患者的AQP4-Ab阳性检出率为20.00%(3/15);单次发作长节段横贯性脊髓炎(m LETM)患者的AQP4-Ab阳性检出率为0;复发长节段横贯性脊髓炎(r LETM)患者的AQP4-Ab阳性检出率为40.00%。结论血清AQP4-Ab生理活性物质在各类型中枢神经系统脱髓鞘疾病群体中均存在一定程度的阳性检出可能。
Objective To investigate the diagnostic value of serum aquaporin 4 antibody (AQP4-Ab) in demyelinating diseases of central nervous system. Methods A total of 98 patients with demyelinating diseases of the central nervous system admitted to the First People’s Hospital of Yulin City from August 2013 to November 2016 were selected for determination of the physiological active substances of serum AQP4-Ab. Results In our study, the positive rate of AQP4-Ab was 27.78% (5/18) in patients with transverse myelitis (TM) and 13.33% (2/3) in patients with optic neuritis (ON) 15). The positive rate of AQP4-Ab in optic neuromyelitis (NMO) was 43.48% (10/23). The positive rate of AQP4-Ab in MS patients was 10.00% (2/20) ; AQP4-Ab positive rate was 20.00% (3/15) in patients with non-long segment transverse myelitis (nLETM); AQP4-Ab in patients with long-segment transverse myelitis (m LETM) The positive detection rate was 0; AQP4-Ab positive rate was 40.00% in patients with recurrent long segment myeloma (r LETM). Conclusions The serum AQP4-Ab physiologically active substances may be detected to some extent in all kinds of demyelinating diseases of the central nervous system.