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目的了解本地区凝固酶阴性葡萄球菌(CNS)致新生儿败血症的病原学及耐药性状况,用以指导临床治疗。方法回顾性分析64株CNS致新生儿败血症血培养的病原学及耐药性。结果 64株CNS中以表皮葡萄球菌和溶血葡萄球菌为主;耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)39株,分离率为60.9%,β-内酰胺酶检出率达100%,MRCNS对青霉素、红霉素、苯唑西林耐药率最高,对利福平、呋西地酸、替考拉宁、喹奴普汀/达福普汀等耐药率均较低;甲氧西林敏感凝固酶阴性葡萄球菌(MSCNS)25株,分离率为39.1%,β-内酰胺酶检出率为44%,MSCNS对大多数抗生素敏感;64株CNS中未检测到万古霉素耐药株。结论新生儿败血症中CNS以表皮葡萄球菌和溶血葡萄球菌为主,MRCNS检出率高且呈多重耐药,应重视对其监测与控制。
Objective To understand the etiology and drug resistance of neonatal sepsis caused by coagulase-negative staphylococci (CNS) in the region to guide the clinical treatment. Methods Retrospective analysis of 64 CNS-induced neonatal septicemia blood culture etiology and drug resistance. Results Staphylococcus epidermidis and Staphylococcus haemolyticus were dominant in 64 strains of CNS. 39 strains of methicillin-resistant coagulase-negative staphylococci (MRCNS) were isolated, the isolation rate was 60.9% and the detection rate of β-lactamase was 100% The resistance rates to penicillin, erythromycin and oxacillin were the highest, and the rates of resistance to rifampicin, fuxidipine, teicoplanin and quinupristin / dalfopristin were all low. Methicillin 25 strains of sensitive coagulase-negative staphylococci (MSCNS) were isolated, the isolation rate was 39.1%, the detection rate of β-lactamase was 44%, MSCNS was sensitive to most of the antibiotics; no vancomycin-resistant strains were detected in 64 CNS . Conclusions CNS in neonatal sepsis is mainly Staphylococcus epidermidis and Staphylococcus haemolyticus. The detection rate of MRCNS is high and multidrug resistant. The monitoring and control should be paid more attention to.