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目的 探讨鼻咽癌患者体内多种免疫效应细胞功能的变化规律及其临床意义。方法 分别采用ＡＰＡＡＰ法、斑蝥皮泡法、免疫粘附法及酶免法检测了２９ 例鼻咽癌患者Ｔ细胞亚群、巨噬细胞吞噬率（ＰＲ）及吞噬指数（ＰＩ）、红细胞免疫粘附功能及血清ｓＩＬ２Ｒ水平，并分析其相互关系。结果 鼻咽癌组病人ＣＤ＋３ 细胞、ＣＤ＋４ 细胞、ＣＤ＋４ ／ＣＤ＋８ 比值降低、ＣＤ＋８ 细胞升高，与对照组比较有显著差异（Ｐ＜ ０．０１）；鼻咽癌患者ＰＲ与ＰＩ均显著低于对照组（Ｐ＜ ０．０１）；鼻咽癌组红细胞Ｃ３ｂ 受体花环率（Ｃ３ｂ ＲＲ）显著低于对照组（Ｐ＜ ０．０１），循环免疫复合物花环率（ＩＣＲ）则显著高于对照组（Ｐ＜ ０．０１）；鼻咽癌患者血清ｓＩＬ２Ｒ明显升高。Ⅲ期以上的鼻咽癌患者与Ⅱ期以下组比较上述免疫指标均有显著差异（Ｐ＜ ０．０１）。鼻咽癌组Ｃ３ｂ ＲＲ与ＰＲ及ＣＤ＋４ ／ＣＤ＋８ ，ＰＲ与ＣＤ＋４ ／ＣＤ＋８ 正相关。ｓＩＬ２Ｒ与Ｃ３ｂＲＲ、ＰＲ及ＣＤ＋４ ／ＣＤ＋８ 均显著相关（Ｐ＜ ０．０５）。结论 鼻咽癌患者多种免疫效应细胞功能下降，并随病情进展，免疫功能进一步下降。对鼻咽癌患者多种免疫效应细胞功能的联合检测有助于了解患者免疫功能的整
Objective To investigate the variation of multiple immune effector cells in patients with nasopharyngeal carcinoma and its clinical significance. Methods The T cell subsets, macrophage phagocytic rate (PI), phagocytic index (PI) and erythrocyte immune adhesion of 29 patients with nasopharyngeal carcinoma were detected by APAAP, With function and serum sIL 2R levels, and analyze the relationship between them. Results Compared with the control group, the ratio of CD + 3 cells, CD + 4 cells, CD + 4 / CD + 8 and CD + 8 cells in nasopharyngeal carcinoma patients were significantly lower than those in control group (P <0.01) (P <0.01). The C3b RR of erythrocyte erythrocytes in nasopharyngeal carcinoma group was significantly lower than that in control group (P <0.01), while the ICR of circulating immune complexes was significantly higher than that in control group Group (P <0.01); serum sIL 2R in patients with nasopharyngeal carcinoma was significantly increased. There were significant differences in the above immune indexes between stage Ⅲ and above NPC patients and those in stage Ⅱ (P <0.01). There was a positive correlation between C3b RR and PR and CD + 4 / CD + 8, PR and CD + 4 / CD + 8 in NPC patients. There was a significant correlation between sIL2R and C3bRR, PR and CD + 4 / CD + 8 (P <0.05). Conclusion The function of multiple immune effector cells in patients with nasopharyngeal carcinoma is decreased. With the progression of the disease, the immune function is further decreased. Joint detection of multiple immune effector cell functions in patients with nasopharyngeal carcinoma helps to understand the patient’s immune function