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缺血/再灌注损伤(I/R)是指对于曾经发生过缺血的组织,重新开放血流时,组织的缺血状态不但没有改善,反而更加加重[1]。缺血/再灌注损伤的发病机制非常复杂,已经广泛认可的机制有以下三种:氧自由基产生增加;钙离子超负荷引起再灌注损伤;中性粒细胞介导的再灌注损伤[2]。国内外的一些学者通过动物实验与临床实验,已经对影响皮瓣缺血再灌注损伤的各类药物进行了研究,发现下列物质或药物能提高缺血皮瓣的成活率。
Ischemia / reperfusion injury (I / R) refers to the ischemic tissue has occurred, the reopening of blood flow, the organization’s ischemic state has not only not improved, but more aggravated [1]. The pathogenesis of ischemia / reperfusion injury is very complicated. There are three widely recognized mechanisms: oxygen free radical production increase; calcium overload overload reperfusion injury; neutrophil-mediated reperfusion injury [2] . Some domestic and foreign scholars through animal experiments and clinical trials, has affected the flap ischemia-reperfusion injury of various drugs have been studied and found that the following substances or drugs can improve the survival rate of ischemic flaps.