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目的 监测丙戊酸钠血药浓度 ,指导癫痫患者个体化用药。方法 以荧光偏振免疫法测定 16 1例癫痫患者丙戊酸钠的血药浓度并结合临床疗效优化治疗方案。结果 血药浓度在 5 0～ 10 0 μg/ml之间的占 49 4%。 5 4例患者经血药浓度监测后调整用药方案而改善了疗效。结论 丙戊酸钠血药浓度监测对临床合理用药具有重要的指导意义。
Objective To monitor the plasma concentration of valproate and guide the individualized medication in patients with epilepsy. Methods Fluorescence polarization immunoassay was used to determine the plasma concentration of sodium valproate in 16 patients with epilepsy and to optimize the treatment regimen in combination with clinical efficacy. Results The plasma concentration was 49 4% between 50 and 100 μg / ml. 5 4 patients after treatment of blood drug concentration monitoring program to improve the efficacy of treatment. Conclusion The monitoring of plasma concentration of valproate has important guiding significance for the rational clinical use of drugs.