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在棉铃虫几乎对所有商品化学农药单剂产生高抗性的今天，应用遗传防治法，如不育剂，既能有效地降低害虫田间种群密度，又是对ＴＰＭ的补充，经过１９８３～１９９７年室内外试验表明，曾在７０年代用于人类男性的避孕药剂———棉酚，能有效地造成棉铃虫雄性不育。我们不必在室内饲养大量的不育虫，直接将不育剂用于田间，取得理想的防治效果。室内试验表明，在棉铃虫交配前，用浓度大于８００ｍｇ／ｋｇ的棉酚液饲喂雄性棉铃虫，能达到１００％的不育效果。１９９５～１９９７年连续三年对棉田一、二、三代棉铃虫３３３３至１０００ｈｍ２示范表明，将３０００ｍｇ／ｋｇ的棉酚与性诱剂、诱食剂结合，全年每ｈｍ２应用棉酚２２５～６７５ｇ，即可造成百株卵量减少５２６％～７２８％，平均６３３％；百株幼虫数减少３４２％～６０８％，平均４５７％；每年减少化防次数７次；皮棉产量增加７８％～１５０％，平均１０９％，将不育剂在田间直接应用，而无需人工饲养、放飞不育虫的方法，世界上还未见报导。
At present, cotton bollworm has high resistance to single commercial chemical pesticide, and applying genetic control methods such as inoculant can not only effectively reduce the population density of pests but also complement the TPM. After 1983-1997 Indoor and outdoor tests showed that gossypol, a contraceptive used in human men in the 1970s, can effectively cause male sterility in cotton bollworms. We do not have to keep a large number of sterile insects indoors, the sterile agent directly to the field, and achieved the desired effect of prevention and treatment. Laboratory tests showed that the male cotton bollworm was fed with a concentration of gossypol at a concentration of more than 800 mg / kg before mating with cotton bollworms to achieve 100% sterility. From 1995 to 1997, the demonstration of the first, second and third generation cotton bollworm from 3333 to 1000hm2 in cotton field showed that 3000mg / kg gossypol was combined with sex attractants and attractants, and gossypol was applied every hm2 25 ~ 675g, the number of eggs of one hundred can be reduced by 526% ~ 728%, with an average of 633%. The number of hundred larvae decreased by 342% ~ 608% with an average of 457% ; Reduce the number of prevention and control 7 times a year; lint yield increased 7 8% ~ 15 0%, an average of 10 9%, the direct application of sterile agents in the field, without artificial feeding, Have not seen on the report.