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目的 :了解药物性肝炎的发病规律 ,加强药物性肝炎的防治。方法 :对 2 16例药物性肝炎的发病规律及临床特征进行分析。结果 :药物性肝炎患者多有明确使用损肝药物史 ,多发生于服药后 10天 45天 ,临床表现无特异性 ,药物性肝炎多发生于长期、联合使用有肝毒性的药物而又无肝功能监测的患者。结论 :影响药物性肝炎的因素有药物的种类 ,持续用药时间 ,联合用药 ,医生对药物性肝炎的认识以及是否指导患者监测肝功能 ,出现肝损害后是否及时停药等
Objective: To understand the incidence of drug-induced hepatitis and strengthen the prevention and treatment of drug-induced hepatitis. Methods: The incidence and clinical characteristics of 2 16 cases of drug-induced hepatitis were analyzed. Results: Patients with drug-induced hepatitis had definite use of the drug of damaging liver, which happened more than 10 days and 45 days after taking the drug. The clinical manifestations were nonspecific. Drug-induced hepatitis mostly occurred in the long-term. Functional monitoring of patients. Conclusion: The factors affecting drug-induced hepatitis are the types of drugs, duration of treatment, combination therapy, doctors’ understanding of drug-induced hepatitis and whether to guide patients to monitor liver function, whether to promptly stop after liver damage, etc.