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目的探讨小剂量左甲状腺素钠片辅助治疗慢性心力衰竭的临床疗效。方法 100例慢性心力衰竭患者,将其随机分为观察组和对照组,每组50例。对照组患者给予常规治疗,观察组患者在对照组基础上加服小剂量左甲状腺素钠片治疗。比较两组患者的治疗效果与心功能指标水平情况。结果观察组总有效率(94.0%)明显高于对照组(74.0%),差异有统计学意义(P<0.05)。两组均未出现不良反应。观察组患者治疗后左心室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI)、心肌舒张早期峰值速度(VE)与舒张晚期峰值速度(VA)的比值(VE/VA)指标水平均明显高于对照组,差异均有统计学意义(P<0.01)。结论小剂量左甲状腺素钠片辅助治疗慢性心力衰竭的临床疗效显著,有助于改善患者的心功能状态,值得临床广泛推广应用。
Objective To investigate the clinical effect of low-dose levothyroxine sodium tablets in the treatment of chronic heart failure. Methods 100 cases of chronic heart failure patients were randomly divided into observation group and control group, 50 cases in each group. Patients in the control group were given routine treatment. Patients in the observation group were treated with low-dose levothyroxine sodium on the basis of the control group. The therapeutic effect and the level of cardiac function in two groups were compared. Results The total effective rate (94.0%) in observation group was significantly higher than that in control group (74.0%), the difference was statistically significant (P <0.05). No adverse reactions occurred in both groups. The ratio of left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac index (CI), peak early diastolic velocity (VE) and late diastolic peak velocity (VE) ) Indicators were significantly higher than the control group, the difference was statistically significant (P <0.01). Conclusions The clinical efficacy of low-dose levothyroxine sodium in adjuvant treatment of chronic heart failure is significant, which can help to improve the cardiac function of patients. It is worthy of wide application in clinic.