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The fertilization process is the net result of a complex sequence of events that collectively result in the fusion of theopposite gametes. The male gamete undergoes continuous morphological and biochemical modifications during spermdevelopment in the testis (spermatogenesis), maturation in the epididymis, and capacitation in the female reproductivetract. Only the capacitated spermatozoa are able to recognize and bind to the bioactive glycan residue(s) on the ovum’sextracellular coat, the zona pellucida (ZP). Sperm-zona binding in the mouse and several other species is believed totake place in two stages. First, capacitated (acrosome-intact) spermatozoa loosely and reversibly adhere to the zona-in-tact ovum. In the second stage tight irreversible binding occurs. Both types of bindings are attributed to the presence ofglycan- binding proteins (receptors) on the sperm plasma membrane and their complementary bioactive glycan units(ligands) on the surface of the ZP. The carbohydrate-mediated adhesion event i
The fertilization process is the net result of a complex sequence of events that collectively result in the fusion of theopposite gametes. The male gamete undergoes continuous morphological and biochemical modifications during spermdevelopment in the testis (spermatogenesis), maturation in the epididymis, and capacitation in the only the capacitated spermatozoa are able to recognize and bind to the bioactive glycan residue (s) on the ovum ’sextracellular coat, the zona pellucida (ZP). Sperm-zona binding in the mouse and several other species is thought totake place in two stages. First, capacitated (acrosome-intact) spermatozoa loosely and reversibly adhere to the zona-in-tact ovum. Both types of bindings are attributed to the presence ofglycan- binding proteins (receptors ) on the sperm plasma membrane and their complementary bioactive glycan units (ligands) on the surface of the ZP. The carbohydrate-mediate d adhesion event i