对单次和重复口服两种奥美拉唑后相对生物利用度的研究

• 作 者: 陈红艳
• 出 处: 国外医学.药学分册
• 发表日期: 1999年02期
• 关键词: 相对生物利用度 质子泵 胃酸分泌 共价结合 omeprazole 选择性抑制 磺酰胺衍生物 壁细胞 肠溶衣 苯并咪唑

奥美拉唑(omeprazole,Omep)是一种选择性抑制壁细胞上的H+/K+-ATP酶或质子泵的苯并咪唑药物。它本身并无活性,但可在壁细胞处转化为有活性的次磺酰胺衍生物,与H+/K+-ATP酶上的巯基发生共价结合,从而抑制胃酸分泌。Omep在碱性环境下较稳定,为防止口服时被胃酸破坏,近年来将...

Omeprazole (Omep) is a benzimidazole drug that selectively inhibits H + / K + -ATPase or proton pumps on parietal cells. It is inactive on its own but can be converted to active sulfenamide derivatives at the parietal cells to covalently bind to sulfhydryl groups on the H + / K + -ATPase, thereby inhibiting gastric acid secretion. Omep in the alkaline environment is more stable, in order to prevent gastric acid damage when orally, in recent years will be ...