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目的探讨急性冠状动脉综合征(ACS)患者中血清C反应蛋白(CRP)、脑钠尿肽(BNP)和D-二聚体的检测水平变化及在ACS发生、发展中的临床意义。方法选取我院住院的64例ACS患者,分为不稳定型心绞痛(UAP)组38例和急性心肌梗死(AMI)组26例,同期30例稳定性心绞痛(SAP),并选取30例健康成年人为对照组。测定4组研究对象血液CRP、BNP及D-二聚体水平,并对检测结果在各组中进行对比研究。结果 ACS患者CRP、BNP、D-二聚体水平显著高于对照组及SAP组(P<0.05),其中AMⅠ组水平明显高于UAP组、SAP组及对照组(P<0.05)。结论 ACS患者血清CRP、BNP、D-二聚体水平明显升高,检测三者水平对ACS的诊断及预后判断具有重要价值。
Objective To investigate the changes of serum C-reactive protein (CRP), brain natriuretic peptide (BNP) and D-dimer in patients with acute coronary syndrome (ACS) and their clinical significance in the occurrence and development of ACS. Methods Sixty-four ACS patients admitted to our hospital were divided into 38 patients with unstable angina pectoris (UAP) and 26 patients with acute myocardial infarction (AMI). 30 patients with stable angina pectoris (SAP) and 30 healthy adults Artificial control group. The blood levels of CRP, BNP and D-dimer were measured in four groups of subjects, and the results were compared in each group. Results The levels of CRP, BNP and D-dimer in patients with ACS were significantly higher than those in control group and SAP group (P <0.05). The levels of AMⅠ in AMI group were significantly higher than those in UAP group, SAP group and control group (P <0.05). Conclusions Serum levels of CRP, BNP and D-dimer in patients with ACS are significantly increased. The detection of these three levels is of great value in the diagnosis and prognosis of ACS.