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急性肺损伤导致的严重低氧血症是引起组织器官损伤的重要原因。已酮可可碱能缓解TNF、大肠杆菌等诱导的急性肺损伤,但尚无对低氧血症影响的报道,亦无对油酸诱导的急性肺损伤影响的研究。本文旨在观察油酸诱导的急性肺损伤中,己酮可可碱对低氧血症及肺血管通透性的影响。 方法 戊巴比妥25mg/kg腹腔注射麻醉豚鼠,气管插管接呼吸机辅助通气,潮气量8ml/kg,呼吸60次/分,间断静注潘可罗宁保持肌松。置入锁骨下动脉、静脉导管。静推油酸15μl/kg复制急性肺损伤模型。动物
Acute lung injury caused by severe hypoxemia is an important cause of tissue and organ damage. Pentoxifylline has been shown to relieve acute lung injury induced by TNF, E. coli, but no reports of hypoxemia and no study of oleic acid-induced acute lung injury. This article aims to observe the oleic acid-induced acute lung injury, pentoxifylline on hypoxemia and pulmonary vascular permeability. Methods Guinea pigs were anesthetized by intraperitoneal injection of pentobarbitone 25mg / kg and ventilated by ventilator with ventilator. The tidal volume was 8ml / kg and the respiration was 60 beats / min. Into the subclavian artery, intravenous catheter. Anesthetize 15μl / kg of oleic acid to duplicate acute lung injury model. animal