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叙述了评价补充铁 (Fe)的生物利用度的最适宜的方法。这种补充物用同位素标记后 ,经粪便监测 ,测量血红蛋白结合 Fe是测量生物利用度的最好方法。体外 Caco- 2细胞可用于快速筛选 ,以预测所吸收物的潜在生物利用度。如果此化合物不能被标记 ,那么口服 Fe和同时静脉给与同位素 Fe在血浆中的出现和消失就可用以对其吸收做定量分析。口服剂量超过 2 5 mg,4～ 6 h内的血浆浓度可提供生物利用度的定性评估。同时也探讨了使 Fe吸收效率的个体间和个体内变异达到最小的标准化问题
Describes the most appropriate method of evaluating the bioavailability of iron supplements (Fe). After this supplement is labeled with an isotope, monitoring via feces and measuring hemoglobin-bound Fe are the best ways to measure bioavailability. In vitro Caco-2 cells can be used for rapid screening to predict the potential bioavailability of the absorbed material. If this compound can not be labeled, the presence and absence of both oral Fe and concurrent intravenous isotope Fe in plasma can be used to quantify its absorption. Plasma concentrations within 4 to 6 h at oral doses of more than 25 mg provide a qualitative estimate of bioavailability. At the same time, standardization issues that minimize the variation in Fe absorption efficiency between individuals and individuals have also been explored