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目的 研究新型吸入麻醉药地氟醚对维库溴铵肌松作用的影响。方法 ４０ 例ＡＳＡⅠ－ Ⅱ级择期腹部手术病人，随机分为两组，各２０ 例，两组均采用表面麻醉下静注芬太尼，异丙酚诱导插管。对照组以异丙酚持续静注维持麻醉，１５ｍｉｎ 后，静脉注射维库溴铵０．０５ｍｇ／ｋｇ ，地氟醚组在吸入６ ％ 地氟醚１５ 分钟后，静脉注射维库溴铵０ ．０５ｍｇ／ｋｇ，使用ＭＨＪ－ ２ 肌松监测仪监测ＴＯＦ情况。结果 对照组和地氟醚组起效时间分别为４．７２ ±１ ．３７ 和３ ．８２ ±１．０９ｍｉｎ，地氟醚组明显缩短，两组Ｔ１ 显现时间为１０ ．０８ ±２．４７ 和１７．３７ ±３ ．７８ｍｉｎ；Ｔ１２５％ 恢复时间为１９．８８ ±５ ．９１ 和２９ ．７８±５ ．７３ｍｉｎ；Ｔ１ 恢复９０％ 时间为３０ ．２５ ±５．２７ 和４９ ．４８±１２．６０ｍｉｎ 地氟醚组明显延长，两组恢复指数分别为１３ ．６７ ±３ ．５３ 和２２ ．８６ ±３ ．５８ｍｉｎ ，地氟醚组延长。结论 吸入１ＭＡＣ地氟醚能明显缩短维库溴铵起效时间，延长维库溴铵的临床作用和恢复时间。
Objective To study the effect of a new inhaled anesthetic agent, desflurane, on the muscle relaxant effect of vecuronium. Methods Forty ASA Ⅰ-Ⅱ patients undergoing elective abdominal surgery were randomly divided into two groups (n = 20 in each group). Both groups received intravenous injection of fentanyl and propofol for intubation. In the control group, continuous intravenous propofol was used to maintain anesthesia. After 15 minutes, vecuronium 0.05 mg / kg was intravenously injected. Desflurane group was intravenously injected with vecuronium 10% for 6 minutes after inhalation of 6% desflurane. 05mg / kg, using the MHJ-2 muscle relaxant monitor TOF situation. Results The onset time of control group and desflurane group were 4.72 ± 1. 37 and 3. 82 ± 1.09min, desflurane group was significantly shorter, T1 showed two groups of 10. 08 ± 2.47 and 17.37 ± 3. 78min; T125% recovery time was 19.88 ± 5. 91 and 29. 78 ± 5. 73min; T1 recovery 90% of the time is 30. 25 ± 5.27 and 49. 48 ± 12.60min desflurane group was significantly longer, recovery index of the two groups were 13. 67 ± 3. 53 and 22. 86 ± 3. 58min, desflurane group extended. Conclusion Inhalation of desflurane with 1 MAC significantly shortened the onset time of vecuronium and prolonged the clinical effect and recovery time of vecuronium.