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作者对英国8个医疗中心的17例发作2次或2次以上化脓性脑膜炎患者进行回顾性分析。17例共有58次发作。首次发作的年龄自4月龄～51岁。男女之比为7:10,13例有顷骨异常者中7例有头部损伤史,其中5例有脑脊液(CSF)鼻漏。首次发作与损伤相隔数周至12年。5例耳部疾患者中4例有慢性中耳炎史。4例免疫缺陷患者均为原发性补体(C_(3b)、C_4、C_5、C_7)缺乏。 58次发作中43份CSF样本(74％)细菌培养阳性,其中30份样本为肺炎球菌。9份为脑膜炎奈瑟氏菌,2份为流感嗜血杆
The authors retrospectively reviewed 17 patients with purulent meningitis at two or more episodes in eight centers in the United Kingdom. 17 cases a total of 58 episodes. The first episode of the age from 4 months to 51 years old. The ratio of males to females was 7:10. Thirteen of 13 patients had a history of head injury, including 5 cases of cerebrospinal fluid (CSF) rhinorrhea. The first attack and injury separated by a few weeks to 12 years. Four of five patients with otitis media had a history of chronic otitis media. All four immunodeficiency patients were deficient in primary complement (C_ (3b), C_4, C_5 and C_7). Of the 58 seizures, 43 CSF samples (74%) were positive for bacterial culture, 30 of which were pneumococci. Nine were Neisseria meningitidis and two were Haemophilus influenzae