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目的 探讨原发性肝癌(PHC)患者乙型肝炎病毒感染状况。方法 应用酶联免疫吸附技术及聚合酶链反应同步检测216例PHC及100例非肝病患者为对照组血液中HBV-M及HBV-DNA。结果 PHC组中,HBV阳性[HBVM及(或)HBV-DNA阳性]195例(903%),其中HBV-M阳性195例(903%),HBV-DNA阳性71例(329%),均分别显著地高于对照组的41例(410%,P<001)及9例(90%,P<001),PHC患者血液中,仅约三分之一存在HBV。结论 PHC发生与HBV感染有关,HBV是PHC发生发展的主要病因之一。
Objective To investigate the status of hepatitis B virus infection in patients with primary liver cancer (PHC). Methods HBV-M and HBV-DNA in blood of 216 patients with PHC and 100 patients with non-hepatic disease were detected by enzyme-linked immunosorbent assay and polymerase chain reaction simultaneously. Results In the PHC group, HBV positive [HBVM and (or) HBV-DNA positive] 195 cases (903%), of which HBV-M positive 195 cases (903%), HBV-DNA positive 71 cases (329%), respectively Significantly higher than the control group of 41 patients (410%, P <001) and 9 patients (90%, P <001), PHC patients in the blood, only about one-third of the presence of HBV. Conclusion The occurrence of PHC is related to HBV infection. HBV is one of the main causes of the development of PHC.