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常用的一些肝功能试验并不能正确地反映损伤肝脏对抗生素的排泄或代谢能力,这与肾功能衰竭时的情况不同。1974年Hit-zenberger等发现在肝硬化患者中,以各种肝功能试验(包括BSP试验)估计磺胺甲基异(口恶)唑(SMZ)和甲氧苄氨嘧啶(TMP)的清除半衰期是不可能的。1966年Bellamy等也指出林肯霉素的血清半衰期和相应的胆红素及转氨酶之间并无相互关系。鉴于上述情况,以下一些基本知识可能有助于肝病时的临床判断和合理用药。
Some commonly used liver function tests do not correctly reflect the ability of the liver to excrete or metabolize antibiotics, unlike the case of renal failure. In 1974, Hit-zenberger et al. Found that in patients with cirrhosis, the clearance half-life of sulfamethoxazole (SMZ) and trimethoprim (TMP) was estimated by various liver function tests (including BSP tests) impossible. Bellamy et al.1966 also pointed out that the lincomycin serum half-life and the corresponding bilirubin and aminotransferase no correlation between. In view of the above, some of the following basic knowledge may contribute to the clinical judgment and rational use of liver disease.