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目的:探讨血清C-反应蛋白(CRP)水平与宫颈癌患者临床病理特征及预后的关系。方法:检测156例宫颈癌患者首次治疗前血清CRP水平,以CRP浓度5mg/L为分界点分为CRP正常组和CRP升高组,分析两组间临床病理特征及预后的差异。结果:CRP水平升高组较CRP正常组FIGO分期更晚、淋巴结转移阳性率更高,差异均有统计学意义(P<0.05)。不同血清CRP水平与患者年龄、组织分级、病理类型差异均无统计学意义(P>0.05)。单因素及多因素生存分析均显示FIGO分期晚、淋巴结转移阳性及术前CRP升高是预后危险因素,而年龄、组织分级和病理类型均不是预后的独立危险因素。结论:CRP检测方便、灵敏度高,可作为宫颈癌患者辅助诊断、治疗及预后评价的指标。
Objective: To investigate the relationship between the serum level of C-reactive protein (CRP) and the clinicopathological features and prognosis of patients with cervical cancer. Methods: Serum CRP levels were measured in 156 patients with cervical cancer before treatment. The patients were divided into CRP normal group and CRP elevated group with CRP concentration of 5 mg / L as the cut-off point. The clinicopathological characteristics and prognosis were analyzed. Results: The CRP level increased later than the normal CRP group FIGO staging, lymph node metastasis positive rate was higher, the difference was statistically significant (P <0.05). There was no significant difference in serum CRP levels and patient age, histological grade and pathological type (P> 0.05). Univariate and multivariate survival analysis showed that FIGO staging, lymph node metastasis and preoperative CRP were risk factors of prognosis, but age, histological grade and pathological type were not independent prognostic risk factors. Conclusion: CRP is convenient and sensitive to detect, which can be used as an index to diagnose, treat and prognose cervical cancer patients.