论文部分内容阅读
目的了解在不同流行时期福州市人群的甲型H1N1流感(甲流)血清抗体水平。方法自2009年11月30日至2010年3月22日,共5次在福州市的4家医院和1家采供血机构随机选择调查对象,每次调查采集400例血清。以血凝抑制试验方法 (haemagglutination inhibition,HI)检测血清HI抗体。结果 5次调查的人群甲流HI抗体阳性率依次为1.75%、8.00%、11.25%、12.50%和14.25%,抗体几何平均滴度(GMT)则分别为5.49、6.81、7.59、8.83和8.54。不同时间段之间抗体阳性率和GMT的差异有显著统计学意义(P<0.01)。4个年龄组中,以6-17岁的抗体阳性率和GMT的增长幅度最大且有显著统计学意义(P<0.01)。男女性别之间抗体水平差异无统计学意义(P>0.05)。在接种甲流疫苗的人群中,抗体阳性率和GMT分别为46.43%和28.99,均显著高于非接种者的7.20%和6.76(P<0.01)。结论至2010年3月20日,福州市人群甲流抗体水平显著提高,已初步形成免疫屏障,但应加强重点人群的防控措施。
Objective To understand the serum antibody level of Influenza A (H1N1) in Fuzhou in different epidemic periods. Methods From November 30, 2009 to March 22, 2010, 5 subjects were randomly selected from four hospitals in Fuzhou and one blood collection and supply institution, and 400 serum samples were collected from each survey. Serum HI antibody was detected by haemagglutination inhibition (HI). Results The positive rates of HI antibody in the five surveys were 1.75%, 8.00%, 11.25%, 12.50% and 14.25%, respectively. The geometric mean antibody titer (GMT) were 5.49, 6.81, 7.59, 8.83 and 8.54, respectively. The difference of antibody positive rate and GMT between different time periods was statistically significant (P <0.01). Among the four age groups, the positive rates of antibody and GMT at 6-17 years old were the largest and statistically significant (P <0.01). There was no significant difference in antibody levels between men and women (P> 0.05). The antibody positive rate and GMT were 46.43% and 28.99 in the group vaccinated with H1N1 vaccine, which were significantly higher than those in non-vaccinated people (7.20% and 6.76, P <0.01). Conclusion As of March 20, 2010, the antibody level of A streptococci in Fuzhou has been significantly increased, and the immune barrier has been initially formed. However, prevention and control measures should be strengthened in key populations.