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目的:通过4例孕妇血清中抗-E产生的原因及配偶相对应抗原的表现型分析,探讨不是所有存在不规则抗体的孕妇都应进行产前新生儿溶血病的预防及治疗。方法:产前免疫血液学检测均采用血型血清学方法。结果:4例孕妇ABO及Rh(D)血型均相合,孕妇血清中均检出抗-E,配偶红细胞上均缺乏相对应抗原。结论:对存在不规则抗体的孕妇,应对抗体产生的原因及配偶对应抗原的表现型进行分析,根据配偶表现型的结果来决定是否进行产前的预防治疗,这对于该血型系统夫妇血型相合的孕妇消除不该有的身心上的压力,减轻孕妇经济负担等方面具有重要作用。
Objective: Through the analysis of the causes of anti-E in the serum of 4 pregnant women and the phenotypes of the corresponding antigens in spouses, it is suggested that not all pregnant women with irregular antibodies should be prevented and treated with hemolytic disease of prenatal neonates. Methods: Prenatal immunological hematology tests were performed using serological methods. Results: All the 4 pregnant women had the same blood group of ABO and Rh (D), and the anti-E was detected in the serum of pregnant women, and the corresponding antigens were lacking on the spleen erythrocytes. CONCLUSIONS: In pregnant women with irregular antibodies, the causes of antibody production and the corresponding phenotypes of the corresponding spouses should be analyzed. Based on the results of spouse phenotype, whether to carry out prenatal prophylaxis should be determined. Pregnant women to eliminate unwanted physical and psychological stress, reduce the financial burden on pregnant women and so has an important role.