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选择肥胖及超重的30名儿童(5～10岁)和50名青少年(12～18岁)作为研究对象,采用2小时口服糖耐量试验(1.75g/kg体重葡萄糖),每半小时测血糖、胰岛素和C肽。胰岛素抵抗用胰岛素抵抗指数来评价,β细胞功能用胰岛素敏感指数和注射葡萄糖30分钟前后的胰岛素和血糖变化来评价。结果10%儿童和13%的青少年存在糖耐量受损,4%的青少年发现患有2型糖尿病。糖耐量受损人群在糖负荷后胰岛素和C肽水平明显升高,而2型糖尿病青少年30分钟胰岛素变化与血糖变化的比是下降的。胰岛素抵抗在糖耐量受损人群中是显著存在的,BMI是糖耐量受损的最好的预测因子。结论在本地区肥胖儿童和青少年中,IGT受损高度流行,IGT受损人群有明显胰岛素抵抗,但β细胞功能未见明显受损。
Obese and overweight children (5 to 10 years old) and 50 adolescents (12 to 18 years old) were selected as study subjects. The oral glucose tolerance test (1.75g / kg body weight glucose) Insulin and C-peptide. Insulin resistance was assessed using the insulin resistance index, and beta cell function was assessed using the insulin sensitivity index and changes in insulin and blood glucose 30 minutes after the injection of glucose. Results 10% of children and 13% of adolescents had impaired glucose tolerance and 4% of adolescents were found to have type 2 diabetes. Insulin and C-peptide levels were significantly increased in impaired glucose tolerance subjects after glucose overload, whereas the ratio of insulin changes to glycemic changes in type 2 diabetic adolescents was decreased over 30 minutes. Insulin resistance is prominent in people with impaired glucose tolerance and BMI is the best predictor of impaired glucose tolerance. Conclusion Among the obese children and adolescents in the region, IGT is highly impaired and IGT-impaired have obvious insulin resistance, but the function of β-cell is not significantly impaired.