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目的:探讨奥曲肽联合奥美拉唑治疗上消化道出血的临床应用效果。方法:选取我院2011年5月-2013年5月间收治的96例上消化道出血患者临床资料进行回顾性分析,根据用药情况随机分为A组、B组及C组,各组32例,A组给予奥曲肽联合奥美拉唑治疗,B组给予单独使用奥曲肽治疗,C组单独给予奥美拉唑治疗,观察三组临床治疗效果、止血时间及再出血情况,并进行分析比对。结果:A组患者总有效率为93.75%,B组患者总有效率为75.00%,C组患者总有效率为28.13%,A组临床疗效显高于B组与C组,差异性显著(P<0.05),具有统计学意义;A组止血时间及再出血率显著低于B组与C组,3组间差异性显著有统计学意义(P<0.05),B组与C组在临床疗效、止血时间及再出血方面差异性不明显(P>0.05)。结论:在治疗上消化道出血时采用奥曲肽联合奥美拉唑临床治疗效果显著高于单独使用奥曲肽和奥美拉唑,能有效达到止血目的,降低再出血情况发生,且不良反应少,安全性高,可作为临床上治疗上消化道出血的首选药物。
Objective: To investigate the clinical effect of octreotide combined with omeprazole in the treatment of upper gastrointestinal bleeding. Methods: The clinical data of 96 patients with upper gastrointestinal hemorrhage admitted in our hospital from May 2011 to May 2013 were retrospectively analyzed. According to the medication situation, the patients were randomly divided into A group, B group and C group, with 32 cases in each group , Group A was treated with octreotide combined with omeprazole, group B was treated with octreotide alone, group C was treated with omeprazole alone, and the clinical effect, bleeding time and rebleeding of the three groups were observed and analyzed. Results: The total effective rate was 93.75% in group A, 75.00% in group B and 28.13% in group C. The clinical efficacy in group A was significantly higher than that in group B and group C (P <0.05), with statistical significance. The bleeding time and rebleeding rate in group A were significantly lower than those in group B and C (P <0.05). The clinical efficacy of group B and C , Bleeding time and rebleeding difference was not significant (P> 0.05). Conclusion: The clinical effect of octreotide combined with omeprazole in the treatment of upper gastrointestinal bleeding is significantly higher than that of octreotide and omeprazole alone, which can effectively achieve the purpose of hemostasis, reduce the occurrence of rebleeding, and less adverse reactions, safety High, can be used as clinical treatment of upper gastrointestinal bleeding drug of choice.