Short-course or long-course radiation therapy as a part of a neoadjuvant regimen for stage Ⅱ & Ⅲ rec

• 作 者: Nan Zhao Christopher J Lin Fei Wang Chi Lin
• 机 构: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA“,”Univ
• 出 处: 中国癌症研究（英文版）
• 发表日期: 2019年6期
• 关键词: Short-course long-course radiation therapy rectal cancer

The aim of this mini-review is to compare and contrast the pros and cons of short-course and long-course neoadjuvant chemoradiation therapy regimens for stage Ⅱ &Ⅲ rectal adenocarcinoma.Multiple trials have demonstrated the equal efficacy and safety of short-course and long-course radiation therapy as a part of neoadjuvant regimens.Published data also shows that total neoadjuvant therapy could be more successful than neoadjuvant chemoradiation followed by adjuvant chemotherapy.This review points out future research directions for patients with locally advanced rectal adenocarcinoma such as comparing total neoadjuvant therapy that contains a short-course of radiation therapy to the standard of care,and evaluating how the sequence of short-course radiation therapy and chemotherapy in the total neoadjuvant therapy impacts the pathological complete response (pCR) rate,local control,and survival outcomes.