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目的:观察颈动脉狭窄患者支架置入术时其认知功能的影响及简易精神评估量表(MMSE)与蒙特利尔认知评估北京版(MoCA)有无相关性。方法:收集124例颈动脉支架置入患者,在支架置入前及置入后1、3、6月分别应用简易精神评估量表(MMSE)、蒙特利尔认知评估北京版(MoCA)、P300检测患者认知功能的变化,同时对患者卒中有无复发进行登记,所有患者意识清楚,能配合完成上述检查。结果:所有患者安全、成功的置入颈动脉支架,无相关并发症出现;支架置入前颈动脉的狭窄率为(84±8.6)%,支架置入以后颈动脉狭窄率为(4.8±3.8)%,狭窄率较术前明显狭窄:支架置入前患者的MMSE、MoCA及P300潜伏期分别为21±3.1、14±3.6 ms,在治疗后随访的1、3及6个月,MMSE、MoCA明显提高而P300明显缩短;MMSE与MocA呈正相关;在随访期内患者无有症状的卒中复发。结论:颈动脉狭窄是导致认知功能障碍的原因之一,颈动脉支架置入可以改善患者认知功能障碍。
Objective: To observe the cognitive function of patients with carotid artery stenosis during stent implantation and whether there is a correlation between MMSE and MoCA (Montreal Cognitive Assessment of Beijing). Methods: A total of 124 carotid stenting patients were enrolled in this study. MMSE, MoCA and P300 were used before and after PCI respectively at 1, 3 and 6 months after PCI. Patients with changes in cognitive function, at the same time, patients with stroke recurrence registration, all patients with a clear understanding that can cooperate to complete the above examination. Results: All patients were safely and successfully placed in the carotid artery stenting without any complications. The stenosis rate of the anterior carotid artery in the stent was (84 ± 8.6)%, and the carotid stenosis rate was (4.8 ± 3.8) )%, The stenosis rate was significantly narrower than that before operation: the MMSE, MoCA and P300 latency of patients before stent implantation were 21 ± 3.1 and 14 ± 3.6 ms, respectively. At 1,3 and 6 months after follow-up, MMSE, MoCA Significantly increased P300 significantly shortened; MMSE and MocA was positively correlated; in the follow-up period in patients with no symptoms of stroke recurrence. Conclusion: Carotid artery stenosis is one of the causes of cognitive dysfunction. Carotid artery stenting can improve cognitive dysfunction in patients.