Scoring the collective effects of SNPs： association of minor alleles with complex traits in model o

• 作 者: YUAN DeJian ZHU ZuoBin TAN Xia
• 机 构: StateKeyLaboratoryofMedicalGenetics,HighPerformanceComputingCenter,DepartmentofCropandAnimalSciences
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2014年9期
• 关键词: 集体效应 模式生物 等位基因 未成年人 SNP 多性状 单核苷酸多态性 MAC地址 collective effects complex traits mino
• 基金项目: We thank E. Andersen, L. Kruglyak （Princeton University, USA）, A. Bendesky, P. McGrath, C. Bargmann （Rockefeller University, USA）, E. Chesler （Jackson Lab, USA）, M. Rockman （New York University, USA）,

It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a nove