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目的探讨Aα纤维蛋白原58G/A基因多态性与血浆纤维蛋白原(Fg)水平、功能及与缺血性脑血管病的相关性。方法用PCRRFLPs技术检测54例缺血性心脑血管病患者和70例健康对照者的Aα58G/A基因多态性;采用血浆Fg功能自动检测系统测定血浆水平及功能。结果A等位基因频率在病例组为0.315,对照组为0.271,2组比较无显著性差异(P>0.05);病例组血浆Fg水平及功能显著高于对照组;病例组A等位基因携带者血浆Fg功能高于GG基因型组(P=0.038)。结论中国汉族人群存在A58G/A基因多态性;虽然缺血性心脑血管病患者不仅血浆Fg水平增高而且伴有Fg功能增强,但A等位基因不显著影响血浆Fg水平,与缺血性心脑血管病的发病无明显关系。
Objective To investigate the association between the 58G / A polymorphism of Aα fibrinogen and the level of plasma fibrinogen (Fg), its function and ischemic cerebrovascular disease. Methods The polymorphism of Aα58G / A gene in 54 patients with ischemic cardio-cerebrovascular disease and 70 healthy controls was detected by PCR-RFLPs. The plasma Fg function was detected by automatic Fg function system. Results The frequency of allele A was 0.315 in the case group and 0.271 in the control group, there was no significant difference between the two groups (P> 0.05). The plasma Fg level and function in the case group were significantly higher than those in the control group Plasma Fg function was higher in the GG genotype group (P = 0.038). Conclusions There is A58G / A gene polymorphism in Chinese Han population. Although plasma Fg level and plasma Fg level are increased in patients with ischemic cardiovascular and cerebrovascular diseases, A allele does not significantly affect plasma Fg level, but is associated with ischemic The incidence of cardiovascular disease no significant relationship.